Effect of Scorbic acid on Hyperlipidemia

هیپرلیپیدمی یکی از مهم ترین ریسک فاکتورهای آترواسکروزیس می باشد که عامل مهمی در بروز بیماریهای قلبی و سکته مغزی است. اگر چه داروهای مفیدی برای کاهش چربی های خون وارد بازار شده ولی تلاش برای یافتن مواد موثرتر و کم عارضه تر همچنان ادامه دارد. با توجه به گزارشات پراکنده مبنی بر احتمال تـأثیر مثبت مصرف ویتامین C بر کاهش چـربی های خون در این تحـقیق تاثیر این ویتامین بر تری گلیـسرید، کلستـرول، لیپو پروتئین با چـگالی پائین (LDL) و لیپو پروتئین با چگالی بالا (HDL)، در بیماران مصرف کننده لیپیدمی ، مورد بررسی قرار گرفت. در یک کارآزمایی بالینی دو سوکور دو گروه 31 نفره از بیماران مبتلا به هیپرلیپیدمی مصرف کننده لواستاتین انتخاب و پس از انجام آزمایشات مربوط به چربی خون، به گروه مورد روزانه 1000 میلی گرم ویتامین C و به گروه شاهد پلاسبو اضافه شد. پس از 10 هفته مجدداً خون بیماران مورد آزمایش قرار گرفت. نتایج مطالعه نشان داد در هیچ یک از فاکتورهای تری گلیسرید، کلسترول و LDL از نظر آماری تغییر حاصل نشده، ولی میزان HDL بیماران تحت درمان با ویتامین C در مقایسه با گروهی که پلاسبو دریافت کرده بودند افزایش پیدا کرده بود (05/0

Medicinal plants for renal injury prevention.

It has been estimated that about 20% of men and 25% of women between the ages of 65 and 74 have some degrees of chronic kidney. This complication is attributed to oxidative stress. Oxidative stress is an important factor contributing to kidney damage by increasing production of oxidants, particularly insufficiency of endogenous antioxidant defense system. Medicinal plants antioxidants are able to ameliorate oxidative induced kidney damage by reduction of lipid peroxidation and enhancement of scavenging ability of antioxidant defense system. Supplementation of medicinal plants antioxidants might be considered important remedies to abrogate pathology of oxidative stress induced kidney damage, however, single antioxidants do not act the same and might not be beneficial

Serum lipoprotein (a) and atherosclerotic changes in hemodialysis patients.

INTRODUCTION Lipoprotein (a) [Lp(a)] is considered as a risk factor for coronary atherosclerotic disorder and an increase in plasma Lp(a) concentration is usually seen in patients with kidney failure. OBJECTIVES We aimed in this study to evaluate the impact of plasma Lp(a) level on early changes of atherosclerotic vessels in stable hemodialysis (HD) patients. PATIENTS AND METHODS In this clinical study 61 patients (50 non-diabetic (F=20 M=30) and 11 diabetic HD patients), receiving maintenance hemodialysis were included and serum Lp(a) was measured. B-mode ultrasonography of carotid intima-media thickness (cIMT) was also determined. RESULTS The mean ±SD of patients Lp(a) was 58.5±19 mg/dL. The mean ±SD of diabetic patients' Lp(a) was 62±12mg/dL and for nondiabetic ones was 57.7± 20mg/dL. In this study the thickening of Intima-media complex in diabetic group was more than non-diabetics, and no significant difference was found of Lp(a) between diabetic and non diabetic HD patients. There was a significant positive association between serum Lp(a) and cIMT. CONCLUSION Accelerated atherosclerosis seen in diabetic hemodialysis patients. Lp(a) might have an important role in progression of atherosclerosis to accelerate progressive atherosclerosis in these patients

Medicinal plants and secondary metabolites for leech control

No

Preventive and curative activity of garlic extract on gentamicin-induced oxidative stress

Background: Nephrotoxicity is a serious side effect of using gentamicin. Garlic is an important component in the complementary medicine. The aim of this study was to find out whether garlic has ameliorative effects on gentamicin-induced nephrotoxicity. Methods: 50 male Wistar rats were divided into 5 groups of 10; I: They kept in the same condition as others without receiving any drug for 10 days and then sacrificed. II: Rats in this group were injected intraperitoneally (i.p.) with 100 mg/kg of gentamicin for 10 consecutive days and then sacrificed. Group III: Rats in this group received garlic juice 20 mg/kg intraperitoneally for 10 days and then sacrificed. IV: Rats in this group received gentamicin for 10 days, then received 20 mg/kg garlic intraperitoneally for the next 10 days and then sacrificed on day 20th. V: Rats in this group received a combination of intraperitoneal gentamicin and garlic 20 mg/kg for 10 days and then sacrificed. Serum blood urea nitrogen (BUN) and creatinine (Cr) were measured and the kidneys were processed for histopathological examinations. All specimens were examined for morphologic parameters involving tubular cells. Findings: The post administration of garlic after gentamicin treatment potentially attenuated the serum levels of BUN and Cr. The pathology damage scores indicated that post administration of garlic after 10 days of gentamicin treatment attenuated the damage score significantly. Conclusion: We concluded that garlic is a nephroprotective drug to attenuate tubular injury by gentamicin